Cutaneous chronic wounds: A worldwide silent epidemic

Abstract

Cutaneous chronic wounds: A worldwide silent epidemic Chronic wounds develop due to the defective regulation of one or more of the complex cellular and molecular processes involved in proper healing. Here Manuela Martins-Green explores novel potential treatments for wound chronicity. When a wound does not heal within 4 weeks or once aftercare has been provided, it's classed as a chronic wound. It is reported that 1-2% of people in developed countries will experience chronic wounds at least once in their lifetime. In the US alone, they impact ~8.5M people and cost ~$28B/year, not accounting for the pain and suffering patients endure, psychologically, physically and financially. There are several types of chronic wounds: Diabetic wounds develop in diabetic patients and are usually localized to the lower limbs, primarily in the foot, and, hence, the name Diabetic Foot Ulcers (DFUs). Pressure ulcers (bed sores), commonly develop in individuals who suffer from impaired sensation, malnutrition or are confined to a wheelchair or bed. Venous and arterial ulcers develop in individuals with impaired circulation. Other wounds that do not heal may develop from a surgery, an accident, chemical exposure, etc.