Nano-Niosomal Formulation of Alkaloids from Vinca rosea for Improved Oral Delivery

Abstract

Phytochemicals, the natural biochemical substances produced by plants possess a range of medicinal values. These phytochemicals get into our system through food and bring different physiological benefits. However, many of these phytochemicals lack essential physicochemical properties that can provide them effective drug-likeness properties. Vinca rosea alkaloids are known for their therapeutic values especially in the cancer treatment domain. However, the physiochemical properties of these molecules limit their bioavailability greatly. This current research aimed at improving the bioavailability of Vinca rosea alkaloids through the nanovector system, niosomes. Vinca alkaloids were extracted, purified, screened and quantified. Niosomal constructs of the alkaloids were made, characterized through scanning electron microscope and ex-vivo studies were carried out using goat intestine. The size of the niosomes was found to be in the range of 400 to 800 nm. Results shows that niosomal formulation can increase bioavailability of Vinca rosea alkaloids two folds compared to the native alkaloid extract.