NCX 470 Reduces Intraocular Pressure More Effectively Than Lumigan in Dogs and Enhances Conventional and Uveoscleral Outflow in Non-Human Primates and Human Trabecular Meshwork/Schlemm's Canal Constructs

Author:

Galli Corinna1,Bastia Elena1,Hubatsch Douglas A.2,Toris Carol34ORCID,Fan Shan3,Unser Andrea5,Ahmed Feryan5,Torrejon Karen Y.5,Impagnatiello Francesco1

Affiliation:

1. Nicox Research Institute, Bresso, Milan, Italy.

2. Nicox Ophthalmics, Durham, North Carolina, USA.

3. University of Nebraska Medical Center, Omaha, Nebraska, USA.

4. The Ohio State University, Columbus, Ohio, USA.

5. Humonix Biosciences Inc., Albany, New York, USA.

Publisher

Mary Ann Liebert Inc

Subject

Pharmacology (medical),Pharmacology,Ophthalmology

Reference42 articles.

1. The Pathophysiology and Treatment of Glaucoma

2. Glaucoma

3. Normal tension glaucoma: review of current understanding and mechanisms of the pathogenesis

4. A Randomized, Controlled Comparison of NCX 470 (0.021%, 0.042%, and 0.065%) and Latanoprost 0.005% in Patients With Open-angle Glaucoma or Ocular Hypertension: The Dolomites Study

5. 6. Fechtner R. NCX 470, a nitric oxide donating bimatoprost, demonstrates non-inferiority to latanoprost in phase 3 Mont Blanc Clinical Trial. In: 2023 American Glaucoma Society Annual Meeting. Austin, TX, USA; 2023.

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