1. Update August 2023 Francine Blei, MD
2. The emerging roles of long noncoding RNAs in lymphatic vascular development and disease
3. Angeli, V. and H. Y. Lim (2023). ``Biomechanical control of Iymphatic vessel physiology and functions.'' Cell Mol Immunol. EPub 06/02/2023. The ever-growing research on Iymphatic biology has clearly identified Iymphatic vessels as key players that maintain human health through their functional roles in tissue fluid homeostasis, immunosurveillance, lipid metabolism and inflammation. It is therefore not surprising that the list of human diseases associated with lymphatic malfunctions has grown larger, including issues beyond Iymphedema, a pathology traditionally associated with Iymphatic drainage insufficiency. Thus, the discovery of factors and pathways that can promote optimal Iymphatic functions may offer new therapeutic options. Accumulating evidence indicates that aside from biochemical factors, biomechanical signals also regulate Iymphatic vessel expansion and functions postnatally. Here, we review how mechanical forces induced by fluid shear stress affect the behavior and functions of Iymphatic vessels and the mechanisms Iymphatic vessels employ to sense and transduce these mechanical cues into biological signals.
4. Astrocyte endfeet may theoretically act as valves to convert pressure oscillations to glymphatic flow