Update February 2022
Author:
Affiliation:
1. NYU Langone Health, Grossman School of Medicine, New York, NY, USA.
Publisher
Mary Ann Liebert Inc
Subject
Cardiology and Cardiovascular Medicine
Link
https://www.liebertpub.com/doi/pdf/10.1089/lrb.2021.29118.fb
Reference110 articles.
1. Update February 2022 Francine Blei, MD, MBA
2. A new severity classification of lower limb secondary lymphedema based on lymphatic pathway defects in an indocyanine green fluorescent lymphography study
3. Suzuki, Y., et al. (2021). ``Surgical Applications of Lymphatic Vessel Visualization Using Photoacoustic Imaging and Augmented Reality.'' J Clin Med 11(1). E-Pub 2022/01/12 Lymphaticovenular anastomosis (LVA) is a widely performed surgical procedure for the treatment of lymphedema. For good LVA outcomes, identifying lymphatic vessels and venules is crucial. Photoacoustic
4. Ang, P. S., et al. (2022). ``The growth and expansion of meningeal Iymphatic networks are affected in craniosynostosis.'' Development 149(1). E-Pub 2021/12/16 Skull malformations are associated with vascular anomalies that can impair fluid balance in the central nervous system. We previously reported that humans with craniosynostosis and mutations in TWIST1 have dural venous sinus malformations. It is still unknown whether meningeal Iymphatic networks, which are patterned alongside the venous sinuses, are also affected. We now show that the growth and expansion of meningeal Iymphatics are perturbed in Twist1 craniosynostosis models. Changes to the local meningeal environment, including hypoplastic dura and venous malformations, affect the ability of Iymphatic networks to sprout and remodel. Dorsal networks along the transverse sinus are hypoplastic with reduced branching. By contrast, basal networks closer to the skull base are more variably affected, showing exuberant growth in some animals, suggesting they are compensating for vessel loss in dorsal networks. Injecting a molecular tracer into cerebrospinal fluid reveals significantly less drainage to the deep cervical Iymph nodes, which is indicative of impaired Iymphatic function. Collectively, our results show that meningeal Iymphatic networks are affected in craniosynostosis, suggesting that the clearance of beta-amyloid and waste from the central nervous system may be impeded.
5. Modelling the coupling of the M-clock and C-clock in lymphatic muscle cells
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