1. E. L. Steele Laboratory, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts.
2. Funding support: The authors are supported by NIH R00CA137167, NIH DP2OD008780, NIH R21AI097745 and NCI Federal Share/Proton Beam Income (TPP), Charles King Trust Fellowship and NIH K99HL111343 (SL).