Development of a High-Throughput Calcium Flux Assay for Identification of All Ligand Types Including Positive, Negative, and Silent Allosteric Modulators for G Protein-Coupled Receptors-Reference-Cited by-同舟云学术

Development of a High-Throughput Calcium Flux Assay for Identification of All Ligand Types Including Positive, Negative, and Silent Allosteric Modulators for G Protein-Coupled Receptors

Published:2012-10 Issue:5 Volume:10 Page:457-467
ISSN:1540-658X
Container-title:ASSAY and Drug Development Technologies
language:en
Short-container-title:ASSAY and Drug Development Technologies

Author:

Noblin Devin J.¹,Bertekap Robert L.²,Burford Neil T.²,Hendricson Adam²,Zhang Litao³,Knox Ronald²,Banks Martyn²,O'Connell Jonathan²,Alt Andrew²

Affiliation:

1. Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut.

2. Bristol-Myers Squibb Company, Wallingford, Connecticut.

3. Bristol-Myers Squibb Company, Pennington, New Jersey.

Publisher

Mary Ann Liebert Inc

Link

http://www.liebertpub.com/doi/pdf/10.1089/adt.2011.443

Reference19 articles.

1. The impact of GPCR structures on pharmacology and structure‐based drug design

2. Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

3. The druggable genome

4. Heterotrimeric G‐proteins: a short history

5. Therapeutic potential of β-arrestin- and G protein-biased agonists

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