SIDT2 Inhibits Phosphorothioate Antisense Oligonucleotide Activity by Regulating Cellular Localization of Lysosomes
Author:
Affiliation:
1. Core Antisense Research, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA.
Publisher
Mary Ann Liebert Inc
Subject
Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry
Link
https://www.liebertpub.com/doi/pdf/10.1089/nat.2022.0055
Reference44 articles.
1. Antisense technology: A review
2. Antisense technology: an overview and prospectus
3. Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs
4. The Interaction of Phosphorothioate-Containing RNA Targeted Drugs with Proteins Is a Critical Determinant of the Therapeutic Effects of These Agents
5. Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides
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