Effects of Pistacia terebinthus L. Subsp. palaestina and Rhus coriaria L. Plants on Some Biochemical Parameters of Brain Tissue of Sprague-Dawley Rats in Experimental Breast Cancer Model

Abstract

In this study, the therapeutic effects of Pistacia terebinthus L. subsp. Palaestina (terebinth) and Rhus coriaria L (sumac) plants on DMBA-induced breast cancer in 66 female Sprague-Dawley rats were investigated through biochemical analysis. The rats were divided into 6 groups as Control, DMBA (7.12-Dimethylbenzanthracene), PT (terebinth), RC (sumac), PT+DMBA and RC+DMBA. DMBA was administered to 8-week-old rats via gavage, a single dose of 80 mg/kg according to body weight. Aqueous extracts of terebinth and sumac were given orally to rats in antioxidant groups 3 days a week. In biochemical studies, changes in activities of the antioxidant enzymes CAT (catalase), GST (glutathione transferase), and SOD (superoxide dismutase) in brain tissues as well as total protein, MDA (malondialdehyde), GSH (glutathione), fatty acid, and vitamin levels were determined. Total protein levels generally reduced in the DMBA group compared to the control group (p