Effect of erastin and G3139 on rat liver mitochondria in chronic alcoholic intoxication-Reference-Cited by-同舟云学术

Effect of erastin and G3139 on rat liver mitochondria in chronic alcoholic intoxication

Published:2023 Issue:1 Volume:69 Page:62-71
ISSN:2310-6905
Container-title:Biomeditsinskaya Khimiya
language:ru
Short-container-title:BIOMED KHIM

Author:

Baburina Yu.L.¹,Zvyagina A.I.¹,Odinokova I.V.¹,Krestinina O.V.¹

Affiliation:

1. Institute of Theoretical and Experimental Biophysics of the Russian Academy of Science, Pushchino, Russia

Abstract

The effect of modulators of VDAC channels — G3139 and erastin on the mitochondrial permeability transition pore (mPTP) functioning and changes in the content of proteins involved in regulation of mPTP (VDAC, CNPase, and TSPO) has been investigated in liver mitochondria of rats with chronic alcohol intoxication. It was shown that the mitochondria of rats treated with ethanol were more sensitive to mPTP induction. Moreover, ethanol induced changes in the expression of mPTP regulator proteins. G3139 and erastin were also able to influence the studied mitochondrial parameters, and they increased their effect in the liver mitochondria of rats treated with ethanol, as compared to the mitochondria of control rats. We hypothesize that the results of this study may help to elucidate the mechanisms of chronic action of ethanol on mitochondria and contribute to the development of new therapeutic strategies for treating the consequences of ethanol-related diseases.

Publisher

Institute of Biochemistry

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

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