Oral amoxicillin plus gentamicin regimens may be superior to the procaine-penicillin plus gentamicin regimens for treatment of young infants with possible serious bacterial infection when referral is not feasible: Pooled analysis from three trials in Africa and Asia

Author:

Longombe Adrien Lokangaka1,Ayede Adejumoke Idowu2,Marete Irene3,Mir Fatima4,Ejembi Clara Ladi5,Shahidullah Mohammod6,Adejuyigbe Ebunoluwa A7,Wammanda Robinson D8,Tshefu Antoinette1,Esamai Fabian3,Zaidi Anita K49,Baqui Abdullah H10,Cousens Simon11

Affiliation:

1. Department of Community Health, Kinshasa School of Public Health, Kinshasa, DR Congo

2. College of Medicine, University of Ibadan, and University College Hospital, Ibadan, Nigeria

3. Department of Child Health and Paediatrics, School of Medicine, Moi University, Eldoret, Kenya

4. Department of Pediatrics and Child Health, The Aga Khan University, Karachi, Pakistan

5. Department of Community Medicine, Ahmadu Bello University Teaching Hospital, Ahmadu Bello University, Zaria, Nigeria

6. Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

7. Department of Paediatrics and Child Health, Obafemi Awolowo University, Ile-Ife, Nigeria

8. Department of Paediatrics, Ahmadu Bello University Teaching Hospital, Ahmadu Bello University, Zaria, Nigeria

9. Bill and Melinda Gates Foundation, Seattle, Washington, United States of America

10. Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

11. Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom

Publisher

International Society of Global Health

Subject

Public Health, Environmental and Occupational Health,Health Policy

Reference39 articles.

1. United Nations Inter-agency Group for Child Mortality Estimation (UN IGME). Levels and Trends in Child Mortality: Report 2021. New York: United Nations Children’s Fund; 2021. Available: https://data.unicef.org/resources/levels-and-trends-in-child-mortality/. Accessed: 16 August 2022.

2. Population-based rates, timing, and causes of maternal deaths, stillbirths, and neonatal deaths in south Asia and sub-Saharan Africa: a multi-country prospective cohort study.;Alliance for Maternal and Newborn Health Improvement (AMANHI) mortality study group;Lancet Glob Health,2018

3. World Health Organization. Pocket book of hospital care for children: guidelines for the management of common childhood illnesses. 2nd ed. Switzerland: World Health Organization; 2013. Available: https://apps.who.int/iris/bitstream/handle/10665/81170/9789241548373_eng.pdf?sequence=1. Accessed: 16 August 2022.

4. Effect of community-based newborn-care intervention package implemented through two service-delivery strategies in Sylhet district, Bangladesh: a cluster-randomised controlled trial.;Baqui;Lancet,2008

5. Effect of home-based neonatal care and management of sepsis on neonatal mortality: field trial in rural India.;Bang;Lancet,1999

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