Intestinal microbiocenosis in patients with recurrent <i>Clostridium difficile</i> infection, ulcerative colitis and irritable bowel syndrome after transplantation of fecal microflora-Reference-Cited by-同舟云学术

Intestinal microbiocenosis in patients with recurrent Clostridium difficile infection, ulcerative colitis and irritable bowel syndrome after transplantation of fecal microflora

Published:2020-09-27 Issue:7 Volume: Page:69-77
ISSN:1682-8658
Container-title:Experimental and Clinical Gastroenterology
language:
Short-container-title:jour

Author:

Shrainer E. V.¹^ORCID,Khavkin A. I.²^ORCID,Vlasov V. V.³

Affiliation:

1. Novosibirsk State University

2. Research and Clinical Institute of Pediatrics at the N.I. Pirogov Russian National Research Medical University

3. Scientific adviser of the Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences

Abstract

Identified significant changes in the intestinal microbiome in patients with inflammatory bowel disease (IBD), serve as the reason for therapeutic interventions in order to correct it. Faecal microbiota transplantation (TFM) is an effective treatment for recurrent or refractoryClostridium difficileinfections, including in patients with inflammatory bowel diseases receiving immunosuppressive and anticytokine therapy.The results of studying the effectiveness of TFM using a filtered aqueous suspension of donors feces in the correction of intestinal microbiocenosis in patients with recurrent Clostridial infection (RCT), ulcerative colitis (UC) and irritable bowel syndrome (IBS) are presented. 2 weeks after the introduction of the supernatant, a suspension of fecal microorganism microorganisms in patients evaluated the dynamics of the total content of microorganisms and individual representatives of the intestinal microflora. It was found that the supernatant of an aqueous suspension of donor feces containing microbial exometabolites and other biologically active compounds in the short term has the most pronounced effect on the restoration of normal intestinal microflora only in patients with clostridial infection.

Publisher

LLC Global Media Technology

Subject

Gastroenterology,Hepatology

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