Chemoreactome analysis of natural and synthetic statins indicates a more favorable safety profile of monacolin K

Abstract

Increasing the effectiveness and safety of pharmacotherapy of hyperlipidemia is an urgent task of gastroenterology and cardiology. Statin drugs can differ signifi cantly not only in the effectiveness of lipid profile normalization, but also in the spectrum of side effects. The paper presents the results of a comparative chemoreactomic analysis of “natural” statins (monacolins K, J, L, simvastatin) and synthetic statins (atorvastatin, fl uvastatin). It is important to note that “natural” monacolin K does not cause the negative metabolic changes characteristic of synthetic statins. In general, the assessments of the accumulation of the studied molecules in various human cells and tissues, effects on the human metabolome and proteome, and assessments of the side effects of therapy indicate a more favorable safety profile of the “natural” statin monacolin K.