Affiliation:
1. Federal Research Center “Informatics and Management”, Russian Academy of Sciences
2. V. N. Orekhovich Research Institute of Biomedical Chemistry
Abstract
Human placenta hydrolysates (HPH) have a pronounced hepatoprotective effect, the molecular mechanisms of which are not well understood. As a result of de novo mass spectrometric sequencing and bioinformatics analysis of peptides, 27 peptides were found in the Laennec HPP preparation, which (1) support inositol phosphate-dependent signaling pathways of hepatocytes, (2) activate the target proteins RARA, AMPK, and (3) inhibit target proteins Notch1, GSK-3, PAK1 and TLR4. By exhibiting anti-inflammatory, antifibrotic, vasodilatory, antiatherosclerotic, and antidiabetic properties, these peptides can make a significant contribution to the hepatoprotective properties of HLP.
Publisher
LLC Global Media Technology
Subject
Gastroenterology,Hepatology
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