Relationship between cardiometabolic risk factors and 25(OH)D levels in young men with non-alcoholic fatty liver disease

Abstract

Purpose of the study. Search for the relationship between cardiometabolic risk factors and 25(OH)D levels in young men with NAFLD. Materials and methods. A one-time study was carried out. The study included 102 men aged 18 to 44 years with no complaints and a verified diagnosis of NAFLD. NAFLD was confirmed in 70 people. All patients were divided into two groups: group I - persons with NAFLD (n=70); group II - persons without NAFLD (n=32); age differences are not statistically significant. All patients included in the study underwent laboratory and instrumental examination. Results. In 68.6% of men aged 18 to 44 years who had no previous complaints and a verified diagnosis of NAFLD, this diagnosis was made, of which steatosis of the liver was diagnosed in 100% of cases, NASH was diagnosed in 60.0%, in 34, 3% liver fibrosis on the background of steatosis and NASH, pathological changes in the liver in most cases were of a combined nature and increased with the progression of steatosis. Cardiometabolic risk factors such as abdominal obesity, NASH, and arterial hypertension predominate in patients with NAFLD. Patients with NAFLD showed a significant increase in laboratory markers of cardiometabolic risk against the background of insufficient supply of 25(OH)D; these disorders worsen as steatosis progresses. The identified relationships indicate a high cardiovascular risk and a worse prognosis for the life of young men with NAFLD. In patients with NAFLD, the number of laboratory markers of cardiometabolic risk is 4 or more in one patient, while their peers without NAFLD have no more than 2 components. Conclusion. Expanding our understanding of the role of vitamin D in pathological mechanisms in young people with NAFLD will make it possible to control the progression of insulin resistance through timely screening and vitamin D supplementation.