Probiotics and hepatoprotectors in the treatment of acute viral hepatitis

Abstract

Relevance. In patients with acute viral hepatitis A and B, favorable conditions are created for the development of dysbiotic changes. As a result, the toxic load on the liver increases. For effective treatment of acute viral hepatitis A and B, the combined administration of probiotics and hepatoprotectors is necessary. Aim. To study the clinical course, the functional state of the liver, the intestinal microflora in patients with acute viral hepatitis A and B, and the effectasy of using a combination of probiotics and hepatoprotectors to correct the intestinal microflora. Materials and methods. The work used clinical and laboratory data of 74 patients with AVHA and AVHB. The main group of patients received complex therapy with probiotics and hepatoprotectors on the background of basic therapy. The comparison group patients were on conventional therapy. Clinical, biochemical, bacteriological parameters were observed before the start of therapy and 15 days later, serological markers - upon admission. Results. In patients with AVHA and AVHB of the main group, the main clinical manifestations disappeared significantly earlier than in the control group. Patients of the main group with AVHA after treatment had significantly lower values of ALT, total bilirubin, indirect bilirubin, cholesterol than in the control group. Patients with AVHB who received complex treatment, after its completion, had values of ALT, total, direct bilirubin and cholesterol significantly lower than control group. After the treatment in the main group, a significant increase in the total number of bifidobacteria was revealed, and in the main group, patients with AVHA after treatment showed a significant increase in the total number of E. coli. Conclusion. The use of combination therapy with probiotics and hepatoprotectors against the background of basic treatment in patients with acute viral hepatitis A and B has a positive effect on clinical parameters, the functional state of the liver and intestinal microbiocenosis.