Abstract
Introduction: Bronchopulmonary dysplasia (BPD) is a common respiratory morbidity in preterm infants. The onset of pulmonary hypertension leads to worse respiratory outcomes. The contribution of left ventricular diastolic dysfunction in BPD-PH is well reported. We evaluated the serial left ventricular function and possible ventricular interdependence among BPD-PH. Methods: This is a single-center, prospective observational study. Infants <28 weeks of gestation are included. Results: Eighty infants were enrolled. The incidence of BPD-PH was 23%. The BPD-PH group had a high incidence of hemodynamically significant ductus arteriosus (83% vs. 56%, p < 0.018), longer oxygen days (96.2 ± 68.1 vs. 59.35 ± 52, p < 0.008), and prolonged hospital stay (133.8 ± 46 vs. 106.5 ± 38 days, p < 0.005). Serial tissue Doppler imaging showed prolonged left ventricle (LV) isovolumetric contraction time (IVCT) (31.05 ± 3.3 vs. 26.8 ± 4.4 ms, p < 0.001) and myocardial performance index (MPI) (0.43 ± 0.03 vs. 0.37 ± 0.04, p < 0.001) from 33 weeks. The changes in IVCT (35.9 ± 6.7 vs. 27.9 ± 4.5 ms, p < 0.001), isovolumetric relaxation time (IVRT) (50 ± 6.5 vs. 39.9 ± 5.8 ms, p < 0.001), and MPI (0.48 ± 0.05 vs. 0.36 ± 0.03, p < 0.001) persisted at 36 weeks. The receiver operator characteristic curve showed LV MPI >40 has 83% sensitivity and 65% specificity (AUC: 0.77, p < 0.001) in the diagnosis of PH. The BPD-PH group had a higher LV E/E′ ratio (13.1 ± 4.4 vs. 11.4 ± 3.4, p < 0.02). Pearson correlation test showed a moderate positive correlation between RV MPI and LV MPI (r = 0.585, p < 0.001). Conclusions: Significant LV diastolic dysfunction was observed in BPD-PH. This is the first study to show biventricular strain and possible ventricular interdependence in BPD-PH. The prolonged LV IVRT and MPI may be a novel echocardiographic indicator of BPD-PH.