Author:
Wu Jian,Hao Jie,Du Yifan,Cao Kai,Lin Caixia,Sun Runzhou,Xie Yuan,Wang Ningli
Abstract
Background: Previous studies identified myopia as a risk factor for primary open-angle glaucoma (POAG). However, recent studies have shown different results, the definitive relationship between myopia and POAG remains controversial.
Objectives: To investigate the relationship between myopia and POAG.
Methods: Published articles were searched from PubMed, Embase, and Scopus databases between 1970 and 2020. A pooled analysis of the ORs was performed using a random-effects model.
Results: Data on the association between myopia and POAG, were obtained from 16 cross sectional studies, and the pooled OR was 2.26 (95% confidence interval [CI], 1.77 – 2.89, P < 0.001) in random effects model (I2 = 86%; P < 0.01). For the relationship of myopia and POAG progression, data from seven longitudinal cohort studies were included and the pooled OR was 0.85 (95% CI, 0.73 – 0.99, P = 0.042) in the random-effects model (I2 = 88%; P < 0.01).
Conclusion: Our findings demonstrated that myopia may be a risk factor associated with POAG and a possible protective factor for POAG progression. It may due to myopia with the presence of a lamina cribrosa defect slow down the visual field loss also POAG progression, further research for underlying mechanisms is still needed.
Subject
Cellular and Molecular Neuroscience,Sensory Systems,Ophthalmology,General Medicine
Cited by
3 articles.
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