<i>MTNR1B</i> rs1387153 Polymorphism and Risk of Gestational Diabetes Mellitus: Meta-Analysis and Trial Sequential Analysis

Abstract

<b><i>Background:</i></b> Published data on the association between the <i>MTNR1B</i> rs1387153 polymorphism and gestational diabetes mellitus (GDM) risk are controversial. <b><i>Objective:</i></b> A meta-analysis was performed to assess whether the polymorphism of <i>MTNR1B</i> rs1387153 is associated with GDM risk. <b><i>Method:</i></b> Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Databases were searched to identify eligible studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for <i>MTNR1B</i> rs1387153 polymorphism and GDM were appropriately derived from fixed-effects or random effects models. <b><i>Results:</i></b> A total of 8 studies were enrolled in this meta-analysis. The pooled analyses revealed that <i>MTNR1B</i> rs1387153 polymorphism significantly increased the risk of GDM in all models (allele contrast (C vs. T): OR, 0.78; 95% CI, 0.73–0.83; homozygote (CC vs. TT): OR, 0.61; 95% CI, 0.53–0.69; heterozygote (CT vs. TT): OR, 0.78; 95% CI, 0.69–0.89; dominant model (CC + CT vs. TT): OR, 0.71; 95% CI, 0.63–0.80; recessive model (CC vs. CT + TT): OR, 0.73; 95% CI, 0.67–0.81). Further subgroup analyses by ethnicity of participants yielded similar positive results. <b><i>Conclusions:</i></b> Present meta-analysis reveals that <i>MTNR1B</i> rs1387153 variant may serve as genetic biomarkers of GDM.