Prevalence of Parkinson’s Disease in Adults Aged 65 Years and Older in China: A Multicenter Population-Based Survey

Abstract

Background: Parkinson’s disease (PD) is a common neurodegenerative disease. With the aging of the Chinese population, it is important to understand the prevalence of PD in the elderly. Objective: Little data are available on the current prevalence of PD in China. The aim of this study was to determine the prevalence of PD in Chinese individuals aged 65 years and older and to analyze associated risk factors. Methods: We performed a population-based cross-sectional survey using a multistage cluster sampling design. Residents aged 65 years and older were drawn from 11 urban districts and 10 rural counties across China. Data were entered into spreadsheets and analyzed using SPSS 24. Results: We identified 151 patients with PD among 8,124 residents aged 65 years and over, including 75 men and 76 women. The overall prevalence of PD in the study population was 1.86%, and the standardized prevalence of PD was 1.60%. The crude prevalence in men (2.12%) was higher than that in women (1.66%) and the standardized prevalence in urban areas (1.98%) was higher than that in rural areas (1.48%). Logistic regression analysis showed that independent risk factors for PD were older age, heavy metal or pesticide exposure, urban residence, rapid eye movement sleep behavior disorder, and heart disease. Conclusions: The prevalence of PD among individuals aged 65 years and older in China has remained constant. The prevalence of PD is higher in men than in women and higher in urban areas than in rural areas.