Author:
Horikoshi Akira,Iriyama Noriyoshi,Hirabayashi Yukio,Kodaira Hitomi,Matsukawa Yoshihiro,Uchino Yoshihito,Takahashi Hiromichi,Hatta Yoshihiro,Takeuchi Jin,Kobayashi Sumiko,Miura Katsuhiro
Abstract
<b><i>Background:</i></b> Elderly acute myeloid leukemia (AML) patients and patients with higher-risk myelodysplastic syndromes (MDS) have a much poorer prognosis than younger patients despite intensive chemotherapy. <b><i>Methods:</i></b> Ten patients with higher-risk MDS and 12 patients with AML over 65 years of age were enrolled into this study and received oral induction therapy with cytarabine ocfosfate and etoposide. <b><i>Results:</i></b> The therapy response rates were 60% in the MDS group and 41.7% in the AML group. The difference in overall survival among MDS and AML patients was not statistically significant. The difference in the median survival times of the responsive and nonresponsive groups, which included MDS and AML patients, was statistically significant (790 and 174 days, respectively). <b><i>Conclusions:</i></b> Based on a comparison of the data of this therapy in elderly higher-risk MDS patients versus elderly AML patients, we conclude that this therapy is well tolerated and can be cost-effective and useful for higher-risk MDS in elderly patients.
Cited by
5 articles.
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