Author:
Schöffski Patrick,Vander Borght Sara,Vanden Bempt Isabelle,Jentjens Sander,Vandecaveye Vincent,Sciot Raf,De Hertogh Gert,Christiaens Melissa,Wolthuis Albert
Abstract
<b><i>Introduction:</i></b> We report the case of a young female patient with a technically resectable, nonmetastatic, rectoanal, anaplastic lymphoma kinase gene (<i>ALK</i>)-translocated inflammatory myofibroblastic tumor (IMFT). <b><i>Case Presentation:</i></b> The patient was successfully treated preoperatively with the tyrosine kinase inhibitor (TKI) crizotinib, to downsize the primary tumor, followed by sphincter-sparing surgery, and adjuvant radiotherapy and crizotinib. She is now in follow-up with good sphincter function and with no evidence of active disease. <b><i>Conclusion:</i></b> Pre- and postoperative treatment administration of crizotinib can be given with curative intent to patients with locally advanced, nonmetastatic IMFTs to avoid mutilating surgery.
Subject
Cancer Research,Oncology,Hematology
Cited by
1 articles.
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