Meme kanseri nedeniyle radyoterapi uygulanan hastalarda Tp-e aralığı ve Tp-e/QT oranının prospektif olarak incelenmesi

Abstract

Aims: The aim of this prospective study was to investigate ventricular repolarization using the Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio in breast cancer patients treated with adjuvant radiotherapy(RT) following systemic chemotherapy. Methods: The study was designed as a national, single-center prospective study. According to the treatment protocol, electrocardiograms (ECGs) were taken from all patients on their first and last days of RT. Tp-e intervals, Tp-e/QT ratios, and Tp-e/QTc ratios were calculated based on the ECG recordings. The heart doses due to radiation exposure were examined with mean heart dose, V5, V10,V20, and V30 values. Results: 51 postsurgical patients, who were all treated with AC followed by weekly paclitaxel and had an indication for adjuvant RT, were included in the study. The mean heart dose was observed as median 205 cGy, and the V30 value was 0.01%. When ECG measurements were analyzed, statistically significant increases were observed in Tp-e interval (p