Actividad hipoglucémica de las hojas de Yaca (Artocarpus heterophyllus Lam)

Abstract

Currently, alternatives to the use of drugs to counteract hypoglycemia are being sought through the use of natural medicine. In this sense, this article evaluates the hypoglycemic effect of hydroalcoholic and aqueous extracts of jackfruit leaves (Artocarpus heterophyllus Lam), based on an analysis in experimental models, Rattus rats. Extracts were prepared with concentrations of 125, 250 and 400 ppm. The hypoglycemic analysis was carried out over 15 days, using 45 male rats divided into 9 groups: target, negative control, and positive control. The 8 groups, except for the target group, were administered a diet rich in starch at a concentration of 2000 ppm (mg/kg) of body weight for 15 days, thus carrying out hyperglycemia. Afterward, glycemia was measured on 15 days, intercalated on the first, seventh and fifteenth day, at 30, 60 and 120 minute intervals. The hypoglycemic effect was evidenced in both extracts at a concentration of 400 ppm. In conclusion, the ability of hydroalcoholic and aqueous extracts of Yaka leaves (Artocarpus heterophyllus Lam) on hypoglycemia was evaluated. Keywords: Yaka leaves; hydroalcoholic extract; aqueous extract; hypoglycemic effect; antioxidant activity.