Oral Nano-Delivery Systems for Colon-Targeted Drug Delivery of Traditional Chinese Medicine in Ulcerative Colitis

Author:

Javed Ansari Mohammad1,Hadi Suhad J.2,H. Kzar Hamzah2,Al-Gazally Moaed E.3,Ahmed Hamza Thulfeqar4,Khudair Hasan Mohammed5,Baqir Al-Dhalimy Aiman Mohammed6,Akhavan‐Sigari Reza7

Affiliation:

1. Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj, Saudi Arabia.

2. Veterinary Medicine Collage, Al-Qasim Green University, Al-Qasim, Iraq

3. College of Medicine, University of Al-Ameed, Karbala, Iraq

4. Medical Laboratory Techniques Department, Al-Mustaqbal University College, Babylon, Iraq

5. Al-Manara College of Medical sciences/Department of Pharmacy/Missan/Iraq

6. College of Nursing, Altoosi University College, Najaf, Iraq and The Islamic University, Najaf, Iraq

7. Department of Neurosurgery, University Medical Center Tuebingen, Germany. 8. Department of Health Care Management and Clinical Research, Collegium Humanum Warsaw Management University Warsaw, Poland.

Abstract

Ulcerative colitis (UC) is a type of inflammatory bowel disease with a high recurrence rate. In this regard, sulfasalazine and immunosuppressive medications are often used for an extended period in clinical practice, but their effectiveness is limited, and they are prone to side effects. Modern research has shown that herbal active ingredients of Traditional Chinese Medicine (TCM), such as polyphenols, alkaloids, quinones, and terpenes, have a promising impact on treating UC via a multi-target mechanism and with low side effects. Poor water solubility and low bioavailability of these agents in the gastrointestinal tract are the most challenging issues in delivering these agents to the target tissues. Researchers have created a variety of oral colon-targeted nano-systems of TCM active ingredients in response to the above formulation issues, which significantly improve the treatment of UC by avoiding gastrointestinal damage, prolonging intestinal retention, and achieving controlled drug release at the lesion site. In order to provide ideas for the oral-targeted treatment of UC with active ingredients from TCM, the research progress of an oral colon-targeted nano-system for the treatment of UC is reviewed in the current study, as well as the research progress of an oral colon-targeted nano-system for the treatment of UC. Keywords: Medicine, Chinese Traditional, Colitis, Ulcerative, Nanoparticle Drug Delivery System.

Publisher

Clinical Biotec

Subject

Infectious Diseases,Applied Microbiology and Biotechnology,Epidemiology,Biotechnology

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