The Effect of HNF1A Gene Polymorphism on the Risk of Polycystic Ovary Syndrome in a Sample of Iraqi Women

Author:

Ahmed Toama Elham1,Ahmed Jasim Hamssa1

Affiliation:

1. Institute of Genetic Engineering and Biotechnology for Postgraduate, University of Baghdad, Iraq

Abstract

Polycystic ovary syndrome (PCOS) is one of the most common causes of female infertility. Clinical features caused by high levels of androgens, oligomenorrhea, and polycystic ovarian morphology are necessary for diagnosis. This study aims to find a relationship between the genetic polymorphism of HNF1A and the risk of Polycystic Ovary Syndrome in a Sample of Iraqi Women. The study includes one hundred subjects of Iraqi women in Baghdad (15-35 years); patients were divided into three groups. The first group included Patients treated with metformin, the second group included Patients without metformin, and the third group included healthy. DNA was extracted, then the Genotyping polymorphism (rs1169288) of the HNF1A gene was done by RT-PCR. The AA genotype showed a higher frequency in control (p=0.001), while the CC genotype showed a higher frequency in the patients (p= 0.0001). Keywords: Polycystic ovary syndrome (PCOS), genetic polymorphism, HNF1A protein, Glucose and lipid profile.

Publisher

Clinical Biotec

Subject

Infectious Diseases,Applied Microbiology and Biotechnology,Epidemiology,Biotechnology

Reference51 articles.

1. 1. Bayona, A., et al., Prevalence of PCOS and related hyperandrogenic traits in premenopausal women

2. with type 1 diabetes: a systematic review and meta-analysis. Human Reproduction Update, 2022.

3. 2. Wekker, V., et al., Long-term cardiometabolic disease risk in women with PCOS: a systematic review and meta-analysis. Human reproduction update, 2020. 26(6): p. 942-960.

4. 3. Zhu, T. and M.O. Goodarzi, Causes and consequences of polycystic ovary syndrome: Insights from

5. Mendelian Randomization. The Journal of Clinical Endocrinology & Metabolism, 2022. 107(3): p.

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