Affiliation:
1. Institute of Genetic Engineering and Biotechnology for Postgraduate, University of Baghdad, Iraq
Abstract
Polycystic ovary syndrome (PCOS) is one of the most common causes of female
infertility. Clinical features caused by high levels of androgens, oligomenorrhea,
and polycystic ovarian morphology are necessary for diagnosis. This study aims
to find a relationship between the genetic polymorphism of HNF1A and the risk
of Polycystic Ovary Syndrome in a Sample of Iraqi Women. The study includes
one hundred subjects of Iraqi women in Baghdad (15-35 years); patients were divided into three groups. The first group included Patients treated with metformin,
the second group included Patients without metformin, and the third group included healthy. DNA was extracted, then the Genotyping polymorphism
(rs1169288) of the HNF1A gene was done by RT-PCR. The AA genotype
showed a higher frequency in control (p=0.001), while the CC genotype showed
a higher frequency in the patients (p= 0.0001).
Keywords: Polycystic ovary syndrome (PCOS), genetic polymorphism, HNF1A
protein, Glucose and lipid profile.
Subject
Infectious Diseases,Applied Microbiology and Biotechnology,Epidemiology,Biotechnology
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