Concentration of blood adipokines in patients with chronic obstructive pulmonary disease

Abstract

Aim. To study the serum concentrations of adiponectin and leptin in patients with varying degrees of severity of chronic obstructive pulmonary disease (COPD).Materials and methods. The study included 116 patients divided into two groups: the main group (n = 96) consisting of COPD patients and stratified into four subgroups and a control group (n = 20). The concentration of adiponectin (ng/ml) and leptin was determined by solid-phase enzyme immunoassay (ELISA).Results. Statistically significant differences in serum adiponectin contents were revealed between the control group and COPD patients in stages B, C, and D (p = 0.0004); however, its concentration did not correlate with the body mass index and adipose tissue content. No differences were detected in the concentration of leptin between the groups (p = 0.1288); however, its content correlated with the body mass index (R = –0.710871) and adipose tissue content (R = –0.677900). No noticeable correlation was found between the serum concentrations of adiponectin and leptin (R = –0.098481).Conclusions. The content of individual adipokines demonstrated a different dependence on the anthropometric indicators in COPD patients.