Successful Treatment of an Adolescent With Naegleria fowleri Primary Amebic Meningoencephalitis

Author:

Linam W. Matthew1,Ahmed Mubbasheer2,Cope Jennifer R.3,Chu Craig2,Visvesvara Govinda S.3,da Silva Alexandre J.3,Qvarnstrom Yvonne3,Green Jerril2

Affiliation:

1. Pediatric Infectious Diseases Section and

2. Pediatric Critical Care Section, Arkansas Children's Hospital, Little Rock, Arkansas; and

3. Centers for Disease Control and Prevention, Atlanta, Georgia

Abstract

Naegleria fowleri is a thermophilic, free-living ameba that causes primary amebic meningoencephalitis. The infections are nearly always fatal. We present the third well-documented survivor of this infection in North America. The patient’s survival most likely resulted from a variety of factors: early identification and treatment, use of a combination of antimicrobial agents (including miltefosine), and management of elevated intracranial pressure based on the principles of traumatic brain injury.

Publisher

American Academy of Pediatrics (AAP)

Subject

Pediatrics, Perinatology, and Child Health

Reference24 articles.

1. Successful treatment of primary amebic meningoencephalitis.;Seidel;N Engl J Med,1982

2. Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp, Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea.;Visvesvara;FEMS Immunol Med Microbiol,2007

3. Successful treatment of Naegleria fowleri meningoencephalitis by using intravenous amphotericin B, fluconazole and rifampicin.;Vargas-Zepeda;Arch Med Res,2005

4. Investigational drug available directly from CDC for the treatment of infections with free-living amebae.;Centers for Disease Control and Prevention (CDC);MMWR Morb Mortal Wkly Rep,2013

5. The epidemiology of primary amoebic meningoencephalitis in the USA, 1962-2008.;Yoder;Epidemiol Infect,2010

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