Enterovirus and Parechovirus Coinfection in a Sudden Unexpected Infant Death

Author:

Alidjinou Enagnon Kazali12,Dorsi Di Meglio Marine3,Biron Antoine1,Jeannoel Marion4,Schuffenecker Isabelle4,Gourinat Ann-Claire1

Affiliation:

1. Microbiology Laboratory, Centre Hospitalier Territorial de Nouvelle-Calédonie, Dumbea, New Caledonia;

2. Laboratoire de Virologie ULR 3610, Université Lille, Centre Hospitalier Universitaire de Lille, Lille, France;

3. Service de Néonatologie, Centre Hospitalier Territorial de Nouvelle-Calédonie, Dumbea, New Caledonia; and

4. Laboratoire de Virologie, Centre National de Référence Entérovirus et Parechovirus, Centre Hospitalier Universitaire de Lyon, Lyon, France

Abstract

Viruses are suspected to play a role in the multifactorial pathogenesis of sudden infant death. We described a sudden and unexpected death in a 5-month-old boy, with detection of both enterovirus and parechovirus RNA in the blood. This is the first report of a dual viraemia of enterovirus and parechovirus and its potential association with a sudden unexpected infant death. Extensive sampling and testing especially using molecular methods currently available is needed to better understanding the “hypothetical” link between viral infections and sudden infant death.

Publisher

American Academy of Pediatrics (AAP)

Subject

Pediatrics, Perinatology, and Child Health

Reference18 articles.

1. Centers for Disease Control and Prevention. Sudden unexpected infant death and sudden infant death syndrome: data and statistics. Available at: https://www.cdc.gov/sids/data.htm. Accessed August 15, 2019

2. Sudden infant death syndrome: a review;Goldberg;Pediatr Ann,2018

3. Sudden infant death syndrome and unclassified sudden infant deaths: a definitional and diagnostic approach;Krous;Pediatrics,2004

4. The sudden infant death syndrome;Kinney;N Engl J Med,2009

5. Profiling the approach to the investigation of viral infections in cases of sudden unexpected death in infancy in the Western Cape Province, South Africa;Burger;Forensic Sci Int,2014

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