Fertility Preservation for Pediatric and Adolescent Patients With Cancer: Medical and Ethical Considerations-Reference-Cited by-同舟云学术

Fertility Preservation for Pediatric and Adolescent Patients With Cancer: Medical and Ethical Considerations

Published:2020-03-01 Issue:3 Volume:145 Page:
ISSN:0031-4005
Container-title:Pediatrics
language:en
Short-container-title:

Author:

Klipstein Sigal¹²,Fallat Mary E.³,Savelli Stephanie⁴,Katz Aviva L.,Macauley Robert C.,Mercurio Mark R.,Moon Margaret R.,Okun Alexander L.,Weise Kathryn L.,Rogers Zora R.,Allen Carl,Harper James,Lipton Jeffrey,Wetmore Cynthia,Wilson Hope,Yates Amber,Rescorla Frederick J.,Brandt Mary L.,Caty Michael,Heiss Kurt,Holcomb George W.,Meyers Rebecca L.,Moss R. Lawrence, , ,

Affiliation:

1. Department of Obstetrics and Gynecology, Pritzker School of Medicine, University of Chicago, Chicago, Illinois;

2. InVia Fertility Specialists, Chicago, Illinois;

3. Division of Pediatric Surgery, Hiram C. Polk Jr MD Department of Surgery, University of Louisville, Louisville, Kentucky; and

4. Division of Pediatric Hematology/Oncology, Akron Children’s Hospital, Akron, Ohio

Abstract

Many cancers presenting in children and adolescents are curable with surgery, chemotherapy, and/or radiotherapy. Potential adverse consequences of treatment include sterility, infertility, or subfertility as a result of gonad removal, damage to germ cells as a result of adjuvant therapy, or damage to the pituitary and hypothalamus or uterus as a result of irradiation. In recent years, treatment of solid tumors and hematologic malignancies has been modified in an attempt to reduce damage to the gonadal axis. Simultaneously, advances in assisted reproductive technology have led to new possibilities for the prevention and treatment of infertility. This clinical report reviews the medical aspects and ethical considerations that arise when considering fertility preservation in pediatric and adolescent patients with cancer.

Publisher

American Academy of Pediatrics (AAP)

Subject

Pediatrics, Perinatology, and Child Health

Link

https://publications.aap.org/pediatrics/article-pdf/doi/10.1542/peds.2019-3994/1080052/peds_20193994.pdf

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