Cost-Benefit Analysis of Universal Tandem Mass Spectrometry for Newborn Screening

Author:

Schoen Edgar J.1,Baker John C.1,Colby Christopher J.2,To Trinh T.1

Affiliation:

1. Department of Genetics, Kaiser Permanente Medical Center, Oakland, California

2. Division of Research, Kaiser Permanente Medical Care Program, Oakland, California

Abstract

Objective. To estimate potential costs and benefits of routinely using tandem mass spectrometry (MS/MS) to screen newborns for inborn errors of metabolism. Method. Analysis of costs and benefits resulting from use of MS/MS in screening of 32 000 newborn infants using data from the Kaiser Permanente Medical Care Program of Northern California plus other published data. Setting. A large health maintenance organization. Results. In the base scenario, the cost per quality-adjusted life year saved by MS/MS screening was $5827; in the least favorable scenario, this cost was $11 419, and in the most favorable scenario, $736. Conclusion. Costs per quality-adjusted life year saved by MS/MS screening for inborn errors of metabolism compare favorably with other mass screening programs, including those for breast and prostate cancer.

Publisher

American Academy of Pediatrics (AAP)

Subject

Pediatrics, Perinatology and Child Health

Reference44 articles.

1. Naylor EW, Chace DH. Automated tandem mass spectrometry for mass newborn screening for disorders in fatty acid, organic acid, and amino acid metabolism. J Child Neurol.1999;14(suppl 1):S4–S8

2. Simonsen H, Jensen UG. Technical aspects of neonatal screening using tandem mass spectrometry. Report from the 4th meeting of the International Society for Neonatal Screening. Acta Paediatr Suppl.1999;432:52–54

3. Ciske JB, Hoffman G, Hanson K, et al. Newborn screening in Wisconsin: program overview and test addition. WMJ.2000;99:38–42

4. Muenzer J, Frazier DM, McCandless SE, et al. Incidence and follow-up evaluation of metabolic disorders detected by newborn screening in North Carolina using tandem mass spectrometry. MMWR Morb Mortal Wkly Rep.2001;50(RR03):23–34. Synopses of selected papers presented at the Tandem Mass Spectrometry for Metabolic Disease Screening Among Newborns Workshop, San Antonio, Texas, June 2000. Available at: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5003a2.htm. Accessed May 30, 2002

5. Zytkovicz TH, Johnson D, Rojas D, et al. Testing newborn specimens by tandem mass spectrometry: the first 16 months’ experience in the New England Program. MMWR Morb Mortal Wkly Rep.2001;50(RR03):23–34. Synopses of selected papers presented at the Tandem Mass Spectrometry for Metabolic Disease Screening Among Newborns Workshop, San Antonio, Texas, June 2000. Available at: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5003a2.htm. Accessed May 30, 2002

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3