Unusual Syndrome Among Premature Infants: Association With a New Intravenous Vitamin E Product

Author:

Lorch Vichien1,Murphy M. Dianne1,Hoersten Linda R.1,Harris Eva1,Fitzgerald Jean1,Sinha Sachchida N.1

Affiliation:

1. From the Department of Pediatrics, University of Tennessee Memorial Research Center and Hospital, Knoxville

Abstract

Eight small, premature infants developed an unusual symptom complex of pulmonary deterioration, thrombocytopenia, liver failure, ascites, and renal failure. five infants died; the health of the other three infants improved and they were discharged from the hospital. This unusual syndrome occurred after introduction of a new intravenous vitamin E product (E-Ferol, α-tocopherol acetate) for routine use in the intensive care nursery. Even though no definite conclusion was reached as to its cause, the administration of this intravenous vitamin E product appears to be a significant risk factor.

Publisher

American Academy of Pediatrics (AAP)

Subject

Pediatrics, Perinatology and Child Health

Cited by 9 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Toxicologic Issues in the Neonate;Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose;2007

2. Vitamin E supplementation for prevention of morbidity and mortality in preterm infants;Cochrane Database of Systematic Reviews;2003-10-20

3. Questions and Answers on Labeling of Drugs for Children;Drug Information Journal;1999-04

4. Vitaminversorgung bei unreifen Frühgeborenen;Oxidativer Stress in der Kinderheilkunde;1995

5. Intravenous Immunoglobulin in the Prevention and Treatment of Neonatal Bacterial Sepsis;Advances in Pediatrics;1992

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