The Matrix Metalloproteinase-9 Point-of-Care Test for Dry Eye Disease

Abstract

Dry eye disease (DED) is a condition of the ocular surface characterized by tear film abnormalities and ocular symptoms; ocular surface inflammation is the principal pathogenesis. Recently, a matrix metalloproteinase-9 (MMP-9) point-of-care immunoassay (InflammaDry) has become widely used as an ancillary diagnostic tool in routine clinical settings. This paper reviews the role of MMP-9 in DED, the relationships of MMP-9-positivity on the InflammaDry test with the symptoms and signs of DED, and specific considerations when performing the test.