Large-scale replication and heterogeneity in Parkinson disease genetic loci

Author:

Sharma Manu1,Ioannidis John P.A.1,Aasly Jan O.1,Annesi Grazia1,Brice Alexis1,Van Broeckhoven Christine1,Bertram Lars1,Bozi Maria1,Crosiers David1,Clarke Carl1,Facheris Maurizio1,Farrer Matthew1,Garraux Gaetan1,Gispert Suzana1,Auburger Georg1,Vilariño-Güell Carles1,Hadjigeorgiou Georgios M.1,Hicks Andrew A.1,Hattori Nobutaka1,Jeon Beom1,Lesage Suzanne1,Lill Christina M.1,Lin Juei-Jueng1,Lynch Timothy1,Lichtner Peter1,Lang Anthony E.1,Mok Vincent1,Jasinska-Myga Barbara1,Mellick George D.1,Morrison Karen E.1,Opala Grzegorz1,Pramstaller Peter P.1,Pichler Irene1,Park Sung Sup1,Quattrone Aldo1,Rogaeva Ekaterina1,Ross Owen A.1,Stefanis Leonidas1,Stockton Joanne D.1,Satake Wataru1,Silburn Peter A.1,Theuns Jessie1,Tan Eng-King1,Toda Tatsushi1,Tomiyama Hiroyuki1,Uitti Ryan J.1,Wirdefeldt Karin1,Wszolek Zbigniew1,Xiromerisiou Georgia1,Yueh Kuo-Chu1,Zhao Yi1,Gasser Thomas1,Maraganore Demetrius1,Krüger Rejko1,Boyle R.S2,Sellbach A3,O'Sullivan J.D.4,Sutherland G.T.5,Siebert G.A5,Dissanayaka N.N.W6,Van Broeckhoven Christine7,Theuns Jessie8,Crosiers David9,Pickut Barbara10,Engelborghs Sebastiaan11,Meeus Bram7,De Deyn Peter P.11,Cras Patrick12,Rogaeva Ekaterina13,Lang Anthony E14,Agid Y15,Anheim M15,Bonnet A-M15,Borg M15,Brice A15,Broussolle E16,Corvol JC17,Damier P15,Destée A15,Dürr A15,Durif F15,Lesage S15,Lohmann E15,Pollak P15,Rascol O15,Tison F15,Tranchant C15,Viallet F15,Vidailhet M15,Tzourio Christophe15,Amouyel Philippe18,Loriot Marie-Anne19,Mutez Eugénie20,Duflot Aurélie21,Legendre Jean-Philippe22,Waucquier Nawal22,Gasser Thomas23,Riess Olaf23,Berg Daniela23,Schulte Claudia23,Klein Christine24,Djarmati Ana25,Hagenah Johann25,Lohmann Katja24,Auburger Georg26,Hilker Rüdiger26,van de Loo Simone26,Dardiotis Efthimios27,Tsimourtou Vaia28,Ralli Styliani28,Kountra Persa28,Patramani Gianna28,Vogiatzi Cristina28,Hattori Nobutaka29,Tomiyama Hiroyuki29,Funayama Manabu30,Yoshino Hiroyo31,Li Yuanzhe29,Imamichi Yoko29,Toda Tatsushi32,Satake Wataru32,Lynch Tim33,Gibson J. Mark34,Valente Enza Maria35,Ferraris Alessandro35,Dallapiccola Bruno36,Ialongo Tamara37,Brighina Laura38,Corradi Barbara39,Piolti Roberto40,Tarantino Patrizia41,Annesi Ferdinanda42,Jeon Beom S.43,Park Sung-Sup44,Aasly J45,Opala Grzegorz46,Jasinska-Myga Barbara47,Klodowska-Duda Gabriela47,Boczarska-Jedynak Magdalena47,Tan Eng King48,Belin Andrea Carmine49,Olson Lars49,Galter Dagmar50,Westerlund Marie49,Sydow Olof51,Nilsson Christer52,Puschmann Andreas53,Lin JJ54,Maraganore Demetrius M.55,Ahlskog J, Eric56,de Andrade Mariza57,Lesnick Timothy G.57,Rocca Walter A.58,Checkoway Harvey59,Ross Owen A60,Wszolek Zbigniew K.61,Uitti Ryan J.61

Affiliation:

1. From the Department for Neurodegenerative Diseases (M.S., T.G., R.K.), Hertie Institute for Clinical Brain Research, University of Tübingen, and DZNE, German Centre for Neurodegenerative Diseases, Tübingen, Germany; Stanford Prevention Research Center (J.P.A.I.), Department of Medicine and Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA; Department of Neurology (J.O.A.), St Olavs Hospital and NTNU Trondheim, Trondheim, Norway; Institute of Neurological...

2. Princess Alexandra Hospital, Brisbane , Site Investigator

3. Princess Alexandra Hospital, Brisbane, Site Investigator

4. Royal Brisbane and Women's Hospital Brisbane, Site Investigator

5. Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, QLD, Site Investigator

6. Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, QLD,Site Investigator

7. Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB; and Laboratory of Neurogenetics, Institute Born-Bunge; and University of Antwerp, Antwerpen, Site Investigator

8. Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB; and Laboratory of Neurogenetics, Institute Born-Bunge, and University of Antwerp, Antwerpen, Site Investiagtor

9. Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB; and Laboratory of Neurobiology, Institute Born-Bunge; and University of Antwerp; and Division of Neurology, University Hospital Antwerp, Antwerpen, Site Investigator

10. Memory Clinic and Division of Neurology, ZNA Middelheim, Antwerpen; and Division of Neurology, University Hospital Antwerp, Antwerpen, Site Investigator

11. Laboratory of Neurochemistry and Behavior, Institute Born-Bunge; and University of Antwerp; and Memory Clinic and Division of Neurology, ZNA Middelheim, Antwerpen, Site Investigator

12. Laboratory of Neurobiology, Institute Born-Bunge; and University of Antwerp; and Division of Neurology, University Hospital Antwerp, Antwerpen; Site Investigator

13. Tanz Centre for Research in Neurodegenerative Diseases, Department of Medicine, Division of Neurology, University of Toronto, ON, Canada, Site Investiagtor

14. Movement Disorders Centre, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, Site Investigator

15. Inserm U708, Paris, From the French Parkinson's Disease Genetics Study Group, Site Investigator

16. Inserm U708 E , Paris, From the French Parkinson's Disease Genetics Study Group, Site Investigator

17. Inserm U708 JC , Paris, From the French Parkinson's Disease Genetics Study Group, Site Investigator

18. Inserm U744, Lille, Site Investigator

19. Inserm UMRS775, Paris, Site Investigator

20. Inserm UMR837, Service de Neurologie et de Pathologie du Mouvement CHRU de Lille, Univ Lille Nord de France, Site Investigator

21. UMR837 Inserm-Univ Lille 2, CHRU de Lille, Site Investigator

22. Service de Neurologie et Pathologie du Mouvement, Clinique de Neurologie du CHU de Lille, Site Investigator

23. Department of Neurology, University Hospital Tuebingen, Site Investigator

24. Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Site Investigator

25. Department of Neurology, University of Lübeck, Site Investigator

26. Department of Neurology, Goethe University Frankfurt am Main, Germany, Site Investigator

27. Department of Neurology, Faculty of Medicine, University of Thessaly and Institute of Biomedical Research & Technology, CERETETH, Larissa; Site Investigator

28. Department of Neurology, Faculty of Medicine, University of Thessaly, Larissa, Site Investigator

29. Department of Neurology, Juntendo University School of Medicine, Tokyo, Site Investigator

30. Department of Neurology, and Research Institute for Diseases of Old Age, Graduate School of Medicine, Juntendo University, Tokyo, Site Investigator

31. Research Institute for Diseases of Old Age, Graduate School of Medicine, Juntendo University, Tokyo, Site Investigator

32. Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe, Japan, Site Investigator

33. The Dublin Neurological Institute at the Mater Misericordiae University Hospital, Clinical Investigator at the Conway Institute, University College Dublin, Ireland, Site Investigator

34. Department of Neurology, Royal Victoria Hospital, Belfast, Ireland, Site Investigator

35. IRCCS, Casa Sollievo della Sofferenza Hospital, Mendel Institute, San Giovanni Rotondo, Site Investigator

36. Mendel Institute, Casa Sollievo della Sofferenza Hospital, Rome, Site Investigator

37. Institute of Neurology, Catholic University, Rome, Site Investigator

38. Department of Neurology, Ospedale San Gerarado, Monza, Italy, Site Investigator

39. Department of Paediatrics, University of Milano-Bicocca, Monza, Site Investigator

40. Department of Neurology, Ospedale San Gerardo, Monza, Italy, Site Investigator

41. Institute of Neurological Sciences,National Research Council, Site Investigator

42. Institute of Neurological Sciences, National Research Council, Site Investigator

43. Department of Neurology, Seoul National University Hospital, Site Investigator

44. Department of Laboratory Medicine, Seoul National University Hospital, Site Investigator

45. Department of Neurology, University of Trondheim, Norway, Site Investigator

46. Department of Neurology, Aging, Degenerative and Cerebrovascular Disorders, Medical University of Silesia, Katowice; Site Investigator

47. Department of Neurology, Aging, Degenerative and Cerebrovascular Disorders, Medical University of Silesia, Katowice, Site Investigator

48. National Medical and Biomedical Research Councils, and the Duke-NUS Graduate Medical School, Singapore Millenium Foundation, Site Investigator

49. Department of Neuroscience, KarolinskaInstitutet, Stockholm, Site Investigator

50. Department of Neuroscience, KarolinskaInstitutet, Stockholm; Site Investigator

51. Department of Clinical Neuroscience, Karolinska University Hospital, Stockholm; Site Investigator

52. Department of Geriatric Psychiatry, Lund University; Site Investigator

53. Department of Neurology, Lund University Hospital, Department of Geriatric Psychiatry, Lund University, Site Investigator

54. Department of Neurology, Cushang Show-Chwan Hospital, Taiwan, Site Investigator

55. Department of Neurology, NorthShore Health Systems, Chicago, IL, Site Investigator

56. Department of Neurology, Mayo Clinic, Rochester, MN, USA, Site Investigator

57. Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA, Site Investigator

58. Departments of Neurology and Health Sciences Research, Mayo Clinic, Rochester, MN, USA, Site Investigator

59. Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, Site Investigator

60. Division of Neuroscience, Mayo Clinic, Jacksonville, USA, Site Investigator

61. Department of Neurology, Mayo Clinic, Jacksonville, FL, Site Investigator

Publisher

Ovid Technologies (Wolters Kluwer Health)

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