Author:
Remy P.,de Recondo A.,Defer G.,Loc'h C.,Amarenco P.,Plante-Bordeneuve V.,Dao-Castellana M.-H.,Bendriem B.,Crouzel C.,Clanet M.,Rondot P.,Samson Y.
Abstract
Article abstract-Lesions causing so-called rubral tremors frequently involve the substantia nigra or the nigrostriatal fibers, suggesting dopaminergic denervation as possibly contributory. We examined this hypothesis using PET and (Fluorine-18)-fluorodopa in six patients with a contralateral tremor following a peduncular lesion. The denervation revealed by PET was even more marked than in severe parkinsonian patients. All patients showed partial to complete improvement with levodopa therapy. PET evaluation of D2-receptors with (Bromine-76)bromolisuride showed no asymmetry of the D2 binding despite the important asymmetry of Fluorine-18-fluorodopa uptake. Our results indicate an important involvement of the nigral dopaminergic system in peduncular tremors that appears to be independent of postsynaptic dopamine receptors.NEUROLOGY 1995;45: 472-477
Publisher
Ovid Technologies (Wolters Kluwer Health)
Reference43 articles.
1. Hallett M. Differential diagnosis of tremor. In: Vinken PJ, Bruyn GW, eds. Handbook of clinical neurology, vol 49. Extrapyramidal disorders. Amsterdam: Elsevier, 1986:583-595.
2. The Movement Disorder Society : Constitution and by-laws
Cited by
157 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献