The effects of a new protocol on blood loss in total knee arthroplasty

Author:

Maccagnano Giuseppe1,Pesce Vito1,Noia Giovanni1,Coviello Michele2,Vicenti Giovanni2,Vitiello Raffaele3,Ziranu Antonio3,Spinarelli Antonio2,Moretti Biagio2

Affiliation:

1. Department of Clinical and Experimental Medicine, Orthopedic and Trauma Unit, Faculty of Medicine and Surgery, University of Foggia, Policlinico Riuniti di Foggia

2. University of Bari, AOU Consorziale Policlinico, Bari, Italy

3. Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy

Abstract

The aim of study was to evaluate the efficacy of blood loss prevention with Tranexamic acid in patients undergoing total knee arthroplasty (TKA). The Authors defined a new protocol that foresees the use of Tranexamic acid both pre-intra and post-operatively. Seventy patients indicated for TKA were enrolled. Thirty-five patients (control group) followed standard protocol without Tranexamic acid and the other 35 patients (study group) followed standard protocol with Tranexamic acid. We analyzed the values of hemoglobin (Hb), hematocrit (HCT) and red blood cells (RBCs) both pre-operatively (T0) and post-operatively: immediately after surgery (T1), at one day (T2) and three days post-op (T3). We observed statistical differences at T0 and T3 regarding the Hb, HT and RBCs value between the two groups. Moreover, 11.4% in the study and 28.5% in the control group required blood transfusion. No thrombotic or thrombo-embolic events were reported. We conclude that Tranexamic acid use, as in our protocol, reduces postoperative bleeding in primary knee arthroplasty, with the absence of thrombo-embolic events.

Publisher

Open Medical Publishing

Subject

Orthopedics and Sports Medicine

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