Clinical significance of germline mutations in <i>BRCA1/2</i> gene in pancreatic ductal adenocarcinoma (literature review)-Reference-Cited by-同舟云学术

Clinical significance of germline mutations in <i>BRCA1/2</i> gene in pancreatic ductal adenocarcinoma (literature review)

Published:2024-01-17 Issue:36 Volume: Page:7-12
ISSN:2949-2807
Container-title:Medical alphabet
language:
Short-container-title:Medicinskij alfavit

Author:

Moiseenko V. E.¹^ORCID,Pavlovskii A. V.¹^ORCID,Popov S. A.¹^ORCID,Granov D. A.¹^ORCID,Turlak A. S.¹^ORCID,Avanesyan G. R.²

Affiliation:

1. Russian Scientific Centre of Radiology and Surgical Technologies n. a. academician A.M. Granov

2. Saint Petersburg State Pediatric Medical University

Abstract

Pancreatic ductal adenocarcinoma occupies a leading position in mortality among other malignant neoplasms. The five-year survival of patients is less than 9 %. Risk of a tumor development increases with a mutation in the BRCA gene, however, the effect of this mutation on the clinical course of the disease has been poorly studied and is of certain scientific and practical interest. A review of the world literature on the clinical significance of germline mutations – the risks of malignancy, the choice of treatment tactics – is presented.

Publisher

Alfmed LLC

Subject

Materials Chemistry,Economics and Econometrics,Media Technology,Forestry

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