Affiliation:
1. Russian Scientific Centre of Radiology and Surgical Technologies n. a. academician A.M. Granov
2. Saint Petersburg State Pediatric Medical University
Abstract
Pancreatic ductal adenocarcinoma occupies a leading position in mortality among other malignant neoplasms. The five-year survival of patients is less than 9 %. Risk of a tumor development increases with a mutation in the BRCA gene, however, the effect of this mutation on the clinical course of the disease has been poorly studied and is of certain scientific and practical interest. A review of the world literature on the clinical significance of germline mutations – the risks of malignancy, the choice of treatment tactics – is presented.