Potential Use of Melatonin in Periodontal Disease

Abstract

Melatonin is an indoleamine that is secreted not only in the pineal gland, but also in other organs, in particular the salivary glands. Numerous  studies show that melatonin levels in the saliva and serum of patients suffering from periodontal disease are reduced, suggesting that it may play  an important role in protecting tissues from damage caused by oxidative stress. Melatonin helps regulate the immune response and prevents  periodontal tissue damage. The inclusion of melatonin in the periodontal disease treatment regimen increases its effectiveness. Further research  is needed to determine the optimal forms and dosing regimens for melatonin.