Author:
Sizyakina L P,Andreeva I I
Abstract
In the present study, we describe changes in the immune state of patients with X-linked agammaglobulinemia (X-AGG). We observed the dynamic of the cellular component of the immune system of adaptive and cellular and humoral components of the innate immunity. We investigated parameters of the maturation, differentiation, activation of T-lymphocytes, NK-cells, monocytes, cytokines, antimicrobial peptides in the peripheral blood of these patients. We found the compensatory activation of the effectors systems. We observed decrease of CD4+Foxp3+cells, elevation of the activation functions of T-cells. Microbicidial activity of neutrophils was decreased.
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