Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 expression and its relationship with T cell activation in human immunodeficiency virus/acquired immune deficiency syndrome patients with lung-spleen Qi deficiency syndrome patternEnglish Full Text
LIU Zhen;ZHANG Qingyan;DENG Bowen;SANG Feng;WANG Danni;KANG Ning;LI Jie;ZHANG Min;LIANG Shoupei;DUAN Chenchen;LIU Zhibin;XU Qianlei;LI Qiang;Henan Key Laboratory of Viral Diseases Prevention and Treatment of Traditional Chinese Medicine, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine;Department of Acquired Immune Deficiency Syndrome Treatment and Research Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine;Department of Obstetrics and Gynecology, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine;Medical Department, Medical Department of Zhengzhou People’s Hospital;
Abstract: OBJECTIVE: To investigate the relationship between antiviral restriction factor Sterile Alpha Motif and Histidine-Aspartic acid domain-containing protein 1(SAMHD1) expression and T cell activation, furthermore, identifying objective indexes of lung-spleen Qi deficiency symptom pattern. METHODS: We assessed the profile of T lymphocyte subsets, characteristics of SAMHD1 and human leukocyte antigen DR(HLA-DR) expression in lungspleen Qi deficiency patients. At the same time, people living with human immunodeficiency virus/acquired immune deficiency syndrome(HIV/AIDS)(PLWHA) without obvious clinical symptoms and healthy donors in this area were used as controls. RESULTS: Immunohematologic indexes lower CD4 count, lower CD4/CD8 ratio and higher SAMHD1 level were found in lung-spleen Qi deficiency patients. Furthermore, we demonstrated a positive relationship between SAMHD1 and HLA-DR level as well as with interferon factor in lung-spleen Qi deficiency syndrome and patients without obvious clinical signs and symptoms groups. CONCLUSIONS: These data indicated the positive relationship between SAMHD1 and T cell activation which further elucidated the role of SAMHD1 in cellular immune response. Furthermore, combination of T lymphocyte subsets counts and SAMHD1 level may be used as clinical and biological reference basis for the differentiation and diagnosis of HIV/AIDS traditional Chinese medicine syndromes.
Keywords:
HIV; acquired immunodeficiency syndrome; symptoms complex; SAM domain and HD domain-containing protein 1; T-lymphocytes;
- DOI:
10.19852/j.cnki.jtcm.20220408.004
- Series:
(E) Medicine & Public Health
- Subject:
Traditional Chinese Medicine
- Classification Code:
R259
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