1. From the Department of Emergency Medicine (L.T., X.J., W.B.L., Y.Y., B.L., T.C., X.L.M.), Center for Translational Medicine (E.G., W.K.), and Division of Nephrology (S.P.R., K.S.), Thomas Jefferson University, Philadelphia, Pa, and Inotek Pharmaceuticals Corporation (W.W., G.S.), Cummings Center, Beverly, Mass.