PTPMT1 Is Required for Embryonic Cardiac Cardiolipin Biosynthesis to Regulate Mitochondrial Morphogenesis and Heart Development

Author:

Chen Ze’e12,Zhu Siting12ORCID,Wang Hong1,Wang Li2,Zhang Jianlin2,Gu Yusu2,Tan Changming23,Dhanani Mehul45,Wever Eric678,Wang Xinru1,Xie Boyu1,Wang Shijia1ORCID,Huang Lei1,van Kampen Antoine H.C.89,Liu Jie10,Han Zhen1,Patel Hemal H.45,Vaz Frédéric M.67ORCID,Fang Xi2ORCID,Chen Ju2ORCID,Ouyang Kunfu1ORCID

Affiliation:

1. Department of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen, China (Z.C., S.Z., H.W., X.W., B.X., S.W., L.H., Z.H., K.O.).

2. Departments of Medicine (Z.C., S.Z., L.W., J.Z., Y.G., C.T., X.F., J.C.)

3. Department of Cardiothoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China (C.T.).

4. Anesthesiology (M.D., H.H.P.), School of Medicine, University of California San Diego, La Jolla.

5. Veterans Administration San Diego Healthcare System, CA (M.D., H.H.P.).

6. Departments of Clinical Chemistry and Pediatrics, Amsterdam Gastroenterology Endocrinology Metabolism (E.W., F.M.V.)

7. Core Facility Metabolomics (E.W., F.M.V.), Amsterdam Universitair Medische Centra

8. Laboratory Genetic Metabolic Diseases; Bioinformatics Laboratory, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute (E.W., A.H.C.v.K.), Amsterdam Universitair Medische Centra

9. Biosystems Data Analysis, Swammerdam Institute for Life Sciences (A.H.C.v.K.), University of Amsterdam, The Netherlands.

10. Department of Pathophysiology, School of Medicine, Shenzhen University, Shenzhen, China (J.L.).

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

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