1. From the Department of Cardiovascular Medicine (S.A., Y.I., S.H., T.R., H.U., H.O.), Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan; Molecular Cardiology (Y.A., K.W.), Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA; Division of Reproductive Engineering (T.T., N.N.), Center for Animal Resources and Development, Kumamoto University, Kumamoto, Japan.