The EBC TWO Study (European Bifurcation Coronary TWO)

Author:

Hildick-Smith David1,Behan Miles W.1,Lassen Jens F.1,Chieffo Alaide1,Lefèvre Thierry1,Stankovic Goran1,Burzotta Francesco1,Pan Manuel1,Ferenc Miroslaw1,Bennett Lorraine1,Hovasse Thomas1,Spence Mark S.1,Oldroyd Keith1,Brunel Philippe1,Carrie Didier1,Baumbach Andreas1,Maeng Michael1,Skipper Nicola1,Louvard Yves1

Affiliation:

1. From the Sussex Cardiac Centre, Brighton and Sussex University Hospitals, United Kingdom (D.H.-S., L.B., N.S.); Edinburgh Heart Centre, United Kingdom (M.W.B.); Department of Cardiology, Aarhus University Hospital, Skejby, Denmark (J.F.L., M.M.); Department of Cardiology, San Raffaele Scientific Institute, Milan, Italy (A.C.); Institute Cardiovasculaire Paris Sud, Hospital Privé Jacques Cartier, Massy, France (T.L., T.H., Y.L.); Department of Cardiology, Clinical Centre of Serbia, Belgrade (G.S.);...

Abstract

Background— For the treatment of coronary bifurcation lesions, a provisional strategy is superior to systematic 2-stent techniques for the most bifurcation lesions. However, complex anatomies with large side branches (SBs) with significant ostial disease length are considered by expert consensus to warrant a 2-stent technique upfront. This consensus view has not been scientifically assessed. Methods and Results— Symptomatic patients with large caliber true bifurcation lesions (SB diameter ≥2.5 mm) and significant ostial disease length (≥5 mm) were randomized to either a provisional T-stent strategy or a dual stent culotte technique. Two hundred patients aged 64±10 years, 82% male, were randomized in 20 European centers. The clinical presentations were stable coronary disease (69%) and acute coronary syndromes (31%). SB stent diameter (2.67±0.27 mm) and length (20.30±5.89 mm) confirmed the extent of SB disease. Procedural success (provisional 97%, culotte 94%) and kissing balloon inflation (provisional 95%, culotte 98%) were high. Sixteen percent of patients in the provisional group underwent T-stenting. The primary end point (a composite of death, myocardial infarction, and target vessel revascularization at 12 months) occurred in 7.7% of the provisional T-stent group versus 10.3% of the culotte group (hazard ratio, 1.02; 95% confidence interval, 0.78–1.34; P =0.53). Procedure time, x-ray dose, and cost all favored the simpler procedure. Conclusions— When treating complex coronary bifurcation lesions with large stenosed SBs, there is no difference between a provisional T-stent strategy and a systematic 2-stent culotte strategy in a composite end point of death, myocardial infarction, and target vessel revascularization at 12 months. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT 01560455.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3