1. From the University College Dublin, School of Medicine and Medical Sciences (E.C., C.M.C., S.C.R., S.H., K.H., M.O.L., E.P.C., S.F.F., C.T.T., P.M.) and School of Biomedical and Biomolecular Sciences (F.M.), Dublin, Ireland, and University of Cambridge School of Clinical Medicine, Cambridge, UK (M.S., N.W.M.).