1. From the Department of Cardiovascular, Respiratory, and Metabolic Medicine (F.Z., Y.O., T.Y., B.Y., S.H., S.B., A.K., S.M., C.T.), Department of Public Health (C.K.), Department of Cardiovascular Surgery (G.Y., T.U., R.S.), Graduate School of Medicine, Kagoshima University, Kagoshima, Japan; and Massachusetts General Hospital (R.A.L.), Boston, Mass.