1. From the Second Department of Internal Medicine (S.N., O.S., T.M., Y.Y., K. Shibata, H.T., Y.N., Y.O.), and the Departments of Pharmacology (M.T., K. Sabanai, M.N., N.Y.), and Pathology (A.T., Y.S.), School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, and the Department of Cardiovascular Medicine (H.S.), Tohoku University Graduate School of Medicine, Sendai, Japan.