1. From the Vollum Institute (J.Y., H.N.W., L.A.N., E.W.M.), Oregon Health & Sciences University, Portland; Department of Integrative Physiology (J.Y.), Kyorin University School of Medicine, Tokyo, Japan; and Department of Physiology and Biophysics (L.A.N.), Federal University of Minas Gerais, Belo Horizonte, Brazil.