Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report-Reference-Cited by-同舟云学术

Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report

Published:2023-03 Issue:3 Volume:80 Page:503-522
ISSN:0194-911X
Container-title:Hypertension
language:en
Short-container-title:Hypertension

Author:

Gumz Michelle L.¹^ORCID,Shimbo Daichi²^ORCID,Abdalla Marwah³,Balijepalli Ravi C.⁴,Benedict Christian⁵^ORCID,Chen Yabing⁶^ORCID,Earnest David J.⁷,Gamble Karen L.⁸^ORCID,Garrison Scott R.⁹^ORCID,Gong Ming C.¹⁰^ORCID,Hogenesch John B.¹¹,Hong Yuling⁴,Ivy Jessica R.¹²^ORCID,Joe Bina¹³^ORCID,Laposky Aaron D.¹⁴,Liang Mingyu¹⁵^ORCID,MacLaughlin Eric J.¹⁶^ORCID,Martino Tami A.¹⁷,Pollock David M.¹⁸^ORCID,Redline Susan¹⁹^ORCID,Rogers Amy²⁰^ORCID,Dan Rudic R.²¹^ORCID,Schernhammer Eva S.²²,Stergiou George S.²³^ORCID,St-Onge Marie-Pierre²⁴^ORCID,Wang Xiaoling²⁵,Wright Jacqueline⁴,Oh Young S.⁴

Affiliation:

1. Department of Physiology and Aging; Center for Integrative Cardiovascular and Metabolic Disease, Department of Medicine, Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville, FL (M.L.G.).

2. Department of Medicine, The Columbia Hypertension Center, Columbia University Irving Medical Center, New York, NY (D.S.).

3. Department of Medicine, Center for Behavioral Cardiovascular Health, Columbia University Irving Medical Center, New York, NY (M.A.).

4. Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD (R.C.B., Y.H., J.W., Y.S.O.).

5. Department of Pharmaceutical Biosciences, Molecular Neuropharmacology, Uppsala University, Sweden (C.B.).

6. Department of Pathology, University of Alabama at Birmingham, and Research Department, Birmingham VA Medical Center, AL (Y.C.).

7. Department of Neuroscience & Experimental Therapeutics, Texas A&M University, Bryan, TX (D.J.E.).

8. Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, AL (K.L.G.).

9. Department of Family Medicine, University of Alberta, Canada (S.R.G.).

10. Department of Physiology, University of Kentucky, Lexington, KY (M.C.G.).

11. Department of Pediatrics, University of Cincinnati, OH (J.B.H.).

12. University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, United Kingdom (J.R.I.).

13. Department of Physiology and Pharmacology and Center for Hypertension and Precision Medicine, University of Toledo College of Medicine and Life Sciences, OH (B.J.).

14. National Center on Sleep Disorders Research, Division of Lung Diseases, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD (A.D.L.).

15. Center of Systems Molecular Medicine, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI (M.L.).

16. Department of Pharmacy Practice, Texas Tech University Health Sciences Center, Amarillo, TX (E.J.M.).

17. Center for Cardiovascular Investigations, Department of Biomedical Sciences, University of Guelph, Ontario, Canada (T.A.M.).

18. Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, AL (D.M.P.).

19. Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (S.R.).

20. Division of Molecular and Clinical Medicine, University of Dundee, United Kingdom (A.R.).

21. Department of Pharmacology and Toxicology, Augusta University, GA (R.D.R.).

22. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA (E.S.S.).

23. Hypertension Center, STRIDE-7, National and Kapodistrian University of Athens, School of Medicine, Third Department of Medicine, Sotiria Hospital, Athens, Greece (G.S.S.).

24. Division of General Medicine, Department of Medicine, Columbia University Irving Medical Center‚ New York, NY (M.-P.S.-O.).

25. Georgia Prevention Institute, Department of Medicine, Augusta University, GA (X.W.).

Abstract

Healthy individuals exhibit blood pressure variation over a 24-hour period with higher blood pressure during wakefulness and lower blood pressure during sleep. Loss or disruption of the blood pressure circadian rhythm has been linked to adverse health outcomes, for example, cardiovascular disease, dementia, and chronic kidney disease. However, the current diagnostic and therapeutic approaches lack sufficient attention to the circadian rhythmicity of blood pressure. Sleep patterns, hormone release, eating habits, digestion, body temperature, renal and cardiovascular function, and other important host functions as well as gut microbiota exhibit circadian rhythms, and influence circadian rhythms of blood pressure. Potential benefits of nonpharmacologic interventions such as meal timing, and pharmacologic chronotherapeutic interventions, such as the bedtime administration of antihypertensive medications, have recently been suggested in some studies. However, the mechanisms underlying circadian rhythm-mediated blood pressure regulation and the efficacy of chronotherapy in hypertension remain unclear. This review summarizes the results of the National Heart, Lung, and Blood Institute workshop convened on October 27 to 29, 2021 to assess knowledge gaps and research opportunities in the study of circadian rhythm of blood pressure and chronotherapy for hypertension.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Internal Medicine

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