2024 Recommendations for Validation of Noninvasive Arterial Pulse Wave Velocity Measurement Devices

Author:

Spronck Bart12ORCID,Terentes-Printzios Dimitrios3ORCID,Avolio Alberto P.2ORCID,Boutouyrie Pierre45ORCID,Guala Andrea67ORCID,Jerončić Ana8,Laurent Stéphane45ORCID,Barbosa Eduardo C.D.9,Baulmann Johannes1011ORCID,Chen Chen-Huan12ORCID,Chirinos Julio A.13ORCID,Daskalopoulou Stella S.14ORCID,Hughes Alun D.15ORCID,Mahmud Azra16ORCID,Mayer Christopher C.17ORCID,Park Jeong Bae18ORCID,Pierce Gary L.19ORCID,Schutte Aletta E.2021ORCID,Urbina Elaine M.2223ORCID,Wilkinson Ian B.24,Segers Patrick25ORCID,Sharman James E.26ORCID,Tan Isabella221ORCID,Vlachopoulos Charalambos3ORCID,Weber Thomas27ORCID,Bianchini Elisabetta28ORCID,Bruno Rosa Maria45ORCID,

Affiliation:

1. Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Netherlands (B.S.).

2. Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia (B.S., A.P.A., I.T.).

3. 1st Cardiology Department, Hippokration Hospital, National and Kapodistrian University of Athens, Greece (D.T.-P., C.V.).

4. Université Paris Cité, Inserm, Paris Cardiovascular Research Center (PARCC), France (P.B., S.L., R.M.B.).

5. Service de Pharmacologie et Hypertension, Assistance Publique–Hôpitaux de Paris (AP–HP), Hôpital Européen Georges Pompidou, Paris, France (P.B., S.L., R.M.B.).

6. Vall d’Hebron Institut de Recerca, Barcelona, Spain (A.G.).

7. Centro de Investigación en Red en Enfermedades Cardiovasculares (CIBER-CV), Instituto de Salud Carlos III, Madrid, Spain (A.G.).

8. Laboratory of Vascular Aging and Cardiovascular Prevention, Department of Research in Biomedicine and Health, University of Split School of Medicine, Croatia (A.J.).

9. Feevale University, Santa Casa Hospital, Porto Alegre, Brazil (E.C.D.B).

10. Praxis Dres. Gille/Baulmann, Rheinbach, Germany (J.B.).

11. Division of Cardiology, Medical University of Graz, Austria (J.B.).

12. College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan (C.-H.C.).

13. Cardiovascular Division, University of Pennsylvania Perelman School of Medicine and Hospital of the University of Pennsylvania, Philadelphia, PA (J.A.C.).

14. Department of Medicine, Research Institute McGill University Health Centre, McGill University, Montreal, QC, Canada (S.S.D.).

15. Department of Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London, United Kingdom (A.D.H.).

16. Department of Internal Medicine, Pharmacology, and Clinical Research, Shalamar Medical and Dental College, Lahore, Pakistan (A.M.).

17. AIT Austrian Institute of Technology, Center for Health & Bioresources, Medical Signal Analysis, Vienna (C.C.M.).

18. JB Lab and Clinic, Department of Precision Medicine and Biostatistics, Wonju College of Medicine, Yonsei University, Seoul, Republic of Korea (J.B.P.).

19. Department of Health and Human Physiology, University of Iowa, IA (G.L.P.).

20. School of Population Health, University of New South Wales, Sydney, Australia (A.E.S.).

21. The George Institute for Global Health, Sydney, NSW, Australia (A.E.S., I.T.).

22. Cincinnati Children’s Hospital Medical Center, OH (E.M.U.).

23. University of Cincinnati, OH (E.M.U.).

24. Experimental Medicine and Therapeutics, University of Cambridge, United Kingdom (I.B.W.).

25. IBiTech-BioMMedA, Ghent University, Belgium (P.S.).

26. Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia (J.E.S.).

27. Cardiology Department, Klinikum Wels-Grieskirchen, Austria (T.W.).

28. Institute of Clinical Physiology, Italian National Research Council, Pisa (E.B.).

Abstract

BACKGROUND: Arterial stiffness, as measured by arterial pulse wave velocity (PWV), is an established biomarker for cardiovascular risk and target-organ damage in individuals with hypertension. With the emergence of new devices for assessing PWV, it has become evident that some of these devices yield results that display significant discrepancies compared with previous devices. This discrepancy underscores the importance of comprehensive validation procedures and the need for international recommendations. METHODS: A stepwise approach utilizing the modified Delphi technique, with the involvement of key scientific societies dedicated to arterial stiffness research worldwide, was adopted to formulate, through a multidisciplinary vision, a shared approach to the validation of noninvasive arterial PWV measurement devices. RESULTS: A set of recommendations has been developed, which aim to provide guidance to clinicians, researchers, and device manufacturers regarding the validation of new PWV measurement devices. The intention behind these recommendations is to ensure that the validation process can be conducted in a rigorous and consistent manner and to promote standardization and harmonization among PWV devices, thereby facilitating their widespread adoption in clinical practice. CONCLUSIONS: It is hoped that these recommendations will encourage both users and developers of PWV measurement devices to critically evaluate and validate their technologies, ultimately leading to improved consistency and comparability of results. This, in turn, will enhance the clinical utility of PWV as a valuable tool for assessing arterial stiffness and informing cardiovascular risk stratification and management in individuals with hypertension.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Internal Medicine

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